Posts Tagged ‘antidepresssant interactions with tamoxifen’

buy_TamoxifenBloomberg News (6/3, Rapaport) reports, “US regulators may warn patients taking tamoxifen, a breast cancer medicine…not to use certain types of antidepressants because they block the tumor-fighting drug’s effectiveness.” According to Karen Riley, a spokeswoman for the FDA, the agency is considering “‘adding new information to the tamoxifen label’ to advise women taking the cancer drug against using some antidepressants.” The move follows new evidence, presented a study May 30 at the meeting of the American Society of Clinical Oncology, that “tumors were more than twice as likely to return after two years in women taking the antidepressants while on the cancer drug, compared with those taking tamoxifen alone.” The drug works with “a liver enzyme called CYP2D6 to morph into an active tumor fighter,” but “many antidepressants use the same enzyme, sapping supplies.” Riley added that “the FDA may add details on CYP2D6 to the tamoxifen label.”

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