Researchers associate schizophrenia subtype with particular chromosome region.

MedWire (10/14, Czyzewski) reports that, according to a study published in the Archives of General Psychiatry, patients with schizophrenia “who have particularly severe negative symptoms appear to share a genetic vulnerability at chromosome 1q.” Researchers from Australia’s Queensland Centre for Mental Health Research “performed genetic analysis of 1,236 Han Chinese individuals with a DSM-IV diagnosis of schizophrenia who were members of a large affected sibling-pair sample,” using “latent class (LC) analysis to stratify patients into subgroups.” The team found that a condition “resembling deficit schizophrenia” was “significantly linked to chromosome 1q23-25 with a” logarithm of odds “score of 3.78.”

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