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Posts Tagged ‘JAMA. 2009;302(24):2663-2670’

According to a December article in the Journal of the American Medical Association  (JAMA. 2009;302(24):2663-2670. http://tinyurl.com/ginko-dementiaGinkgo Biloba did not slow the rates of global or domain-specific cognitive decline in older adults.  The herbal product Ginkgo Biloba is taken frequently with the intention of improving cognitive health in aging.  However, evidence from adequately powered clinical trials is lacking regarding its effect on long-term cognitive functioning.   The Ginkgo Evaluation of Memory (GEM) study, a randomized, double-blind, placebo-controlled clinical trial of 3069 community-dwelling participants aged 72 to 96 years, was conducted in 6 academic medical centers in the United States between 2000 and 2008.  Twice-daily dose of 120-mg extract of G biloba or identical-appearing placebo were given.  Rates of change over time in the Modified Mini-Mental State Examination and in neuropsychological domains of memory, attention, visual-spatial construction, language, and executive functions were evaluated .  Annual rates of decline in the scores did not differ between G biloba and placebo groups in any domains, including memory, attention, visuospatial abilities, language and executive functions.  Compared with placebo, the use of G biloba, 120 mg twice daily, did not result in less cognitive decline in older adults with normal cognition or with mild cognitive impairment.

 

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