Posts Tagged ‘Post-Strep OCD’

PandaMedscape (9/30, Cassels) reported that research from the UK indicates that “streptococcal infections (SIs) do not appear to cause or trigger obsessive compulsive disorder (OCD) or Tourette syndrome (TS) — findings that run contrary to several earlier smaller studies.” According to the paper published online Sept. 30 in Neurology, “SI can induce autoimmune neuropsychiatric disorders, in particular Syndenham chorea.” Thus, scientists have speculated that “the association may extend to tic disorders, OCD, and other neuropsychiatric disorders with onset in childhood.” In other words, “the process of molecular mimicry, where by antibodies directed against bacterial antigens cross-react with brain targets,” has been implicated in the pathogenesis of pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS).  But, after reviewing data on “4,774 children and young adults in the UK,” WebMD (9/30, Hitti) reported that researchers at the UK’s University College London “found no evidence of that connection.” Investigators were quick to point out, however, “that their findings don’t rule out any possibility of such a link, but that a very large, prospective study that ‘may be prohibitively expensive’ isn’t supported by current evidence.”

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