Medwire (10/23, Davenport) reports, “Disrupted in schizophrenia 1 (DISC1) gene variants play a role in the development of psychiatric illness yet there is significant heterogeneity in clinically relevant variants between populations,” according to a study (http://tinyurl.com/DISC1-gene) in Molecular Psychiatry. “Although schizophrenia, schizoaffective disorder, bipolar disorder (BD), major depression, autism, and Asperger syndrome have all been linked to DISC1, no actual causal variants have been identified.” But, after genotyping study participants “for the presence of 75 single nucleotide polymorphisms (SNPs) in the translin-associated protein X and DISC1 genes,” investigators discovered that “rs1538979 SNP was significantly associated with BD I males” and “the rs821577 SNP was significantly linked with BD females…at odds ratios of 2.73 and 1.64, respectively.”
Posts Tagged ‘schizoaffective disorder’
Psychiatric Illnesses May Share Common Genetic Variant.
Posted in Bipolar disorder, Depression, Genetics, Schizophrenia, tagged and Asperger syndrome, Autism, bipolar disorder (BD), DISC1 and mental illness, Disrupted in schizophrenia 1 (DISC1) gene variants, major depression, schizoaffective disorder, Schizophrenia on October 25, 2009| Leave a Comment »
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