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Posts Tagged ‘SSRI’

Bloomberg News (1/14, Lopatto) reports that, according to a study published in the Jan. 14 issue of the Journal of the American Medical Association, “Certain antidepressants lessen the distress of pain and sleep disturbances for fibromyalgia patients, boosting their quality of life.” Winfried Hauser, M.D., of the Klinikum Saarbruecken, and colleagues, conducted a meta-analysis of “18 randomized trials, with a combined 1,427 participants.”
        WebMD (1/13, Boyles) noted that the trials contained “patients taking different classes of antidepressants, including low doses of tricyclic and tetracyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), serotonin and noradrenaline reuptake inhibitors (SNRI), and monoamine oxidase inhibitors (MAOIs).” Using “a standardized model to assess the effectiveness of the medications on common fibromyalgia symptoms,” researchers found that the “TCA amitriptyline (Elavil, Endep), given in low doses, had the largest effect on pain, fatigue, and sleep disturbances. Little effect was recorded on depressed mood, however.”
        Based on their findings, the investigators wrote that “since evidence for a long-term effect of antidepressants in [fibromyalgia] is still lacking, their effects should be re-evaluated at regular intervals to determine whether benefits outweigh adverse effects,” HealthDay (1/13, McKeever) reported.
        The condition “affects up to 12 million people (four percent of the U.S. population), nearly 11 million of them women,” Scientific American (1/13, Ballantyne) added. Experts say that the “degree of debilitation caused by the disease ranges ‘from very little to total.'” At present, “there is no definitive test for fibromyalgia, which doctors typically diagnose based on symptoms, including chronic widespread pain.”

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