Posts Tagged ‘TBI treatment’

HealthDay (3/15, Preidt) reported that “a new class of Alzheimer’s disease drugs may prevent long-term damage from traumatic brain injury, suggests a study of mice by Georgetown University Medical Center researchers.” The medications “– gamma-secretase inhibitors — are designed to target amyloid plaque that accumulates in the brains of people with Alzheimer’s disease.” Researchers noted that “people who’ve suffered a brain injury have a 400 percent increased risk of developing Alzheimer’s disease.” For the study, which appears in the journal Nature Medicine, they “first conducted tests that showed that brain injury in mice resulted in substantially more amyloid peptide than normal. They then found that amyloid peptide production after brain injury was reduced in mice that received an experimental agent called DAPT, one of the first gamma secretase inhibitors developed and the basis for some Alzheimer’s disease drugs now in clinical trials.” Their findings “suggest that this class of drugs could do something no other drug has been able to do — prevent the long-term and continuing damage that often follows serious brain injury.” The Press Association (3/16) also covers the story.


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