Posts Tagged ‘treatment resisitant depression’

Research suggests treatment-resistant depression may be associated with reduced global cortical folding surface.  MedWire (3/20, Davenport) reported that, according to a study published in the March issue of the Journal of Psychiatry and Neuroscience, “in unipolar and bipolar patients, treatment-resistant depression is associated with reduced global cortical folding surface.” For the study, researchers from France’s Hôpital Cochin in Paris “studied 16 bipolar disorder patients currently in a treatment-resistant major depressive episode, 25 euthymic bipolar disorder patients, 35 patients with treatment-resistant unipolar depression, and 70 healthy controls.” Using “T1-weighted magnetic resonance imaging (MRI),” the team found that patients with bipolar disorder “with treatment-resistant depression had significantly smaller” hemispheric global sulcal indices (g-SIs) “in the right hemisphere than controls.” Among patients with “treatment-resistant unipolar depression…s-GIs were three to four percent lower in both hemispheres than the corresponding values in controls.” The authors concluded that “reduced cortical folding surface appeared to be a feature of both unipolar depression and bipolar disorder with treatment-resistant depression.”

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